Jack and Kate try to break Marie's resolve so they can learn the location of the bomb. Palmer confronts his ex-wife with the information that Stanton gave them. George finally steps down as director of CTU and hands the position over to Tony. Kim discovers her host's deception.
President Palmer learns of a conflict involving one of his biggest contributors and Wayne. Kim and Michelle question Tony's ability to make decisions. Jack and the Salazars face an unexpected competitor when they go to buy the virus.
Marwan offers to trade Jack for Behrooz in order to distract CTU from possibly investigating the death of an Air Force family. Mitch Anderson runs into problems at the Air Force Base. Meanwhile, on Air Force One, President Keeler is having problems finding a suitable way to address the nation after such a trying day.
Jack is forced to interrogate Audrey when he learned that she might be connected to Bierko and the terrorists. Wayne Palmer and Aaron Pierce flee from armed men who have orders from Christopher Henderson to kill them. Vladimir Bierko and his men execute the next phase of attacks by targeting a gas company and releasing the Sentox gas throughout Los Angeles.
Upon invoking the 25th Amendment, Vice President Daniels shows he is not above perjuring himself in order to obtain the Presidency. Gredenko reluctantly helps CTU capture Fayed. President Palmer resorts to risky medical treatments to maintain consciousness.